💊 Herbs · Limited evidence
St. John's Wort
Herb taken for low mood. People take it for:
- Mood support in mild to moderate depression
- Intense anxiety about physical symptoms (small studies)
- Menopausal hot flashes (small studies)
Why it works
People take it for low mood and symptoms of depression. Studies suggest it may help with mild or moderate depression and works about as well as standard antidepressants there, but its value for severe depression or beyond 12 weeks is uncertain. It interacts with many medicines, so check before using it.
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How to take St. John's Wort
Best time to take
morning-fasted
Suggested dose
500mg
Side effects and risks
- Can weaken many medicines, including antidepressants, birth control pills and blood thinners such as warfarin
- With certain antidepressants it can raise serotonin and cause serious side effects
- Large doses or skin use may cause severe skin reactions after sun exposure
- Can cause diarrhea, dizziness, trouble sleeping, restlessness and skin tingling
St. John's Wort interactions
Caution5-HTP
St John's Wort raises serotonin, and so does 5-HTP. Taking both increases the risk of serotonin excess. Do not combine them without talking to a doctor first.
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Medical disclaimer: Nothing on Stack Ritual constitutes medical advice. The information provided is for educational purposes only. Always consult your doctor or a qualified healthcare provider before beginning, changing, or stopping any vitamin, supplement, or wellness regimen.