5-HTP
Serotonin · sleep · mood · appetite · anxiety. People take it for:
- Serotonin synthesis support
- Sleep quality and onset
- Mood and depression support
- Appetite suppression
- Anxiety reduction
- Migraine prevention
Why it works
5-Hydroxytryptophan (5-HTP) is a direct precursor to serotonin, more potent than tryptophan. Effective for sleep, mood, and appetite control. Use carefully and cycle.
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How to take 5-HTP
Best time to take
30–45 minutes before bed or with meals for mood/appetite
Suggested dose
50–200mg; start at 50mg and increase slowly
Side effects and risks
- Never combine with SSRIs, SNRIs, or MAOIs — serious serotonin syndrome risk
- May cause nausea — start low
- Cycle — do not use continuously long-term
- May cause vivid dreams
5-HTP interactions
CautionL-Tryptophan
5-HTP and L-tryptophan are steps on the same pathway to serotonin, so taking both stacks the same effect and doubles the load. Pick one.
CautionSt. John's Wort
5-HTP raises serotonin, and St John's Wort does the same by a different route. Combining them is one of the few genuinely risky supplement pairings. Speak to a doctor before taking both.