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FOXO4-DRI
peptides · Senolytic peptide targeting aged cells
FOXO4-DRI is a senolytic peptide designed to selectively eliminate senescent ("zombie") cells that resist normal cell death and secrete inflammatory signals. It works by disrupting the FOXO4-p53 interaction that protects senescent cells from apoptosis.
⏱️ Timing & dosage for FOXO4-DRI
Best time to take
3 injections over 5 days (days 1, 3, and 5). 1-3 cycles per year, minimum 4-6 months between cycles.
Suggested dose
1-5 mg per injection, subQ
✅ Benefits of FOXO4-DRI
- •Selectively eliminates senescent cells without harming healthy cells
- •Reduces senescence-associated inflammation
- •Restored physical function in aged animal models
- •Different mechanism than rapamycin or dasatinib+quercetin senolytics
⚠️ Side effects & risks
- •Administered via subQ injection; sourced as a research compound -- verify purity/COA
- •Theoretical risk: p53 pathway disruption in cancer cells -- do not use with active cancer, during chemotherapy, known pulmonary hypertension, or active tissue repair/post-surgery recovery
- •Avoid running regenerative peptides (GHK-Cu, BPC-157, GH secretagogues) during or the week after a cycle
- •Use under medical supervision
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⚕️ Medical Disclaimer: Nothing on Stack Ritual constitutes medical advice. The information provided is for educational purposes only. Always consult your doctor or a qualified healthcare provider before beginning, changing, or stopping any vitamin, supplement, or wellness regimen.